PRP for Erectile Dysfunction

PRP for Erectile Dysfunction


Recently published in the Journal of Sexual Medicine (JSexMed.2021May; 18(5):926-935).  A team of 8 urologists in Greece did a randomized placebo controlled double blind investigation into the safety and efficacy of PRP (Platelet Rich Plasma) injections into the penis of men with mild and moderate erectile dysfunction.

This is the highest level of study with neither the men nor the doctors knowing what treatment that they had. The 60 men were randomly assigned into two groups.  There were two sessions, one month apart where they either had 10mls of PRP or placebo injected deep into the erectile tissue of the penis.  There were 30 men in each group and they were evaluated at 1, 3 and 6 months after completing the two treatments.

The men were not allowed to have any other forms of treatments for erectile dysfunction during this trial. They were assessed using a questionnaire (International Index of Erectile Function-Erectile Domain, IIEF-EF) and they were looking for what is termed a minimal clinical important difference (MCID), so not just a statistical difference between the two but a practical, functional difference from before to after.

At the six month period the MCID was achieved in 20/29 (69%) in the PRP group and 7/26 (27%) in the placebo group. One patient dropped out of the PRP group and 4 out of the placebo group.  There were also significant differences at the one and three month evaluation as well. Not surprisingly, patients receiving the PRP were more satisfied than those receiving placebo and there were no adverse events recorded.

It is certainly encouraging to see this study getting done and then being published in a major journal. The limitations of getting a study done on a treatment like this is that there is no drug company backing and funding it, therefore there is no external push coming to have the treatment studied and publications performed.

As the treatment has been around for a good decade now, this is the first published scientific evidence and I will have to change what I have been saying that there is no scientific support for this.  Hopefully other institutes will perform similar studies but being in the middle of working on our own publications for the CALIBRE procedure, I understand how much hard work is involved in doing it and when you don’t have a drug company funding a researcher to do the work for you, these things tend not to get done.  It is certainly encouraging for us to continue using this treatment for men with erectile dysfunction.

 Link to paper

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